Interaction of disulfiram with antiretroviral medications: Efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism

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Interaction of disulfiram with antiretroviral medications: efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism.

BACKGROUND AND OBJECTIVES Alcohol abuse complicates treatment of HIV disease and is linked to poor outcomes. Alcohol pharmacotherapies, including disulfiram (DIS), are infrequently utilized in co-occurring HIV and alcohol use disorders possibly related to concerns about drug interactions between antiretroviral (ARV) medications and DIS. METHOD This pharmacokinetics study (n=40) examined the e...

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On the interaction of copper(II) with disulfiram.

In combination with copper(II) ions, disulfiram (DSF) has been reported to be a potentially potent anticancer agent based on in vitro results. The interaction of DSF with copper(II) chloride in solution has been studied using a range of spectroscopic techniques. There is strong evidence for the rapid formation of the bis(N,N-diethyl dithiocarbamato)copper(II) complex in situ. Kinetic experiment...

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Compliance with aftercare treatment, including disulfiram, and effect on outcome in alcohol-dependent patients.

AIM To delineate the features of treatment compliance which predicted outcome during aftercare treatment in a series of patients that completed an inpatient program at the Lisbon Regional Alcohology Centre (CRAS). METHODS Seventy-four alcohol dependent patients, sequentially admitted to the inpatient treatment of CRAS, were followed over 6 months after discharge. This study focused on the pre...

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Disulfiram Treatment of Alcoholism

P to the completion of this well­designed scientific study, which was conducted at nine Veterans Administration Medical Centers, the medication disulfiram (Antabuse®) was controversial in the treatment of alcoholism. The controversy over its efficacy was rooted in the lack of sophisticated scientific data on which to base its effectiveness. Fuller and colleagues used state­of­the­art clinical r...

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ژورنال

عنوان ژورنال: The American Journal on Addictions

سال: 2013

ISSN: 1055-0496

DOI: 10.1111/j.1521-0391.2013.12081.x